Beethoven is back -- and this time, he has a whole brood with him now that he's met his canine match, Missy, and fathered a family. The only problem is that Missy's owner, Regina, wants to sell the puppies and tear the clan apart. It's up to Beethoven and the Newton kids to save the day and keep everyone together.
With varying degrees of success, recently divorced friends Dave, Vic and Donny are trying to move on with their lives. Vic feels vilified by his ex-wife's parents, while Donny has a shaky bond with his teen daughter, Emma. Dave, meanwhile, has an enviable problem -- he has more dates than he can handle. As they confront their post-marital challenges, the men take solace in one another's plights.
In order to foil a terrorist plot, an FBI agent undergoes facial transplant surgery and assumes the identity of a criminal mastermind, who murdered his only son. The plan turns sour when the criminal wakes up prematurely and seeks revenge.